1-methyl-5-[(4-methylphenyl)thio]-3-phenyl-4-pyrazolecarbonitrile

1-methyl-5-[(4-methylphenyl)thio]-3-phenyl-4-pyrazolecarbonitrile, also known as **MC136**, is a potent and selective **inhibitor of the enzyme HDAC6**.

**HDAC6** (Histone Deacetylase 6) is a member of the histone deacetylase family of enzymes. It plays a crucial role in regulating various cellular processes, including:

* **Protein degradation**: HDAC6 is involved in the ubiquitin-proteasome pathway, which is responsible for degrading damaged or unnecessary proteins.
* **Microtubule stability**: HDAC6 can deacetylate tubulin, a protein that forms microtubules, influencing their stability and dynamics.
* **Inflammation**: HDAC6 has been implicated in inflammatory responses.

**Why is MC136 important for research?**

MC136's selective inhibition of HDAC6 makes it a valuable tool for researchers studying the role of this enzyme in different biological processes. Specifically, it is used to:

* **Investigate the role of HDAC6 in various diseases**: MC136 has been used to study the involvement of HDAC6 in diseases such as cancer, neurodegenerative disorders, and inflammatory diseases.
* **Develop novel therapeutic strategies**: Targeting HDAC6 with inhibitors like MC136 has shown promise as a therapeutic strategy for these diseases.
* **Uncover the mechanisms of action of HDAC6**: By studying the effects of MC136 on cells and tissues, researchers can gain insights into the specific mechanisms by which HDAC6 exerts its effects.

**Current research on MC136 focuses on:**

* Its potential therapeutic applications in cancer treatment, particularly in multiple myeloma and leukemia.
* Its ability to protect against neuronal damage in neurodegenerative disorders like Alzheimer's and Parkinson's disease.
* Its role in modulating inflammatory responses and potentially treating autoimmune diseases.

**Overall, MC136 is a valuable research tool that has contributed significantly to our understanding of HDAC6 and its role in various physiological and pathological processes. It holds promise for the development of new therapies for a wide range of diseases.**